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Chan,KL
Wong,KKY
Lui,VCH
Saing,H
Cheng,W

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谭广亨
譚廣亨
Tam, Paul Kwong Hang
Tam, PKH
Tam, Paul K. H.
Tam, Kwong Hang
Tam, KH
Paul Tam
Tam P
Tam, Paul
Tam, PK
Tam, Paul K.
Tam, K. H.
Tam, Paul H. K.
Tam, Paul Kwang-Hang
Tam, Paul KwongHang
Paul Kwong Hang Tam
Paul K.H. Tam
Kwong-Hang, Paul
Tam, Paul K.H.
Tam, Paul Kwong-hang
Paul Kwong Hang, Tam
Tam, P. K.
Tam, Paul Kwong-Hang
Tam, Paul K H
Tam PKH
Tam, P. K. H.
Tam, P.
Paul Kwong Hang TAM
Tam, P
Tam, P. K-H
Tam, Pk-H
Tam, Paul KH
Tam, P.K.H.
Tam, Paul Kh
Paul K.H.Tam
TAM, PKH
TAM, P
TAM, PK

譚廣亨

校長辦公室(PO)

ORCID: 0000-0001-6231-3035

ResearcherID: C-4405-2009

成果： 1412 件 | 合作者：2838

WOS核心合集引用：30446 | H Index：58 | WOS收錄：536

CNKI收錄：5 | SCOPUS收錄：549

論文: 1199 | 著作：36 | 科研項目：166 | 專利：11

論文
著作
科研項目
專利

論文: 1199 篇上傳編輯糾錯可能是譚廣亨的文章匯出

1.A systematic review and meta-analysis of the effects of long-term antibiotic use on cognitive outcomes

Ye, Yongqin, Tong, H More...

Scientific Reports[2045-2322], Published 2024, Volume 14, Issue 1,

收錄情况： WOS SCOPUS

WOS核心合集引用: 3 2023影響因子: 3.8

2.Environmental Toxin Biliatresone-Induced Biliary Atresia-like Abnormal Cilia and Bile Duct Cell Development of Human Liver Organoids

Hai-Bing, Y, Sivasan More...

TOXINS[2072-6651], Published 2024, Volume 16, Issue 3,

收錄情况： WOS SCOPUS

WOS核心合集引用: 2 2023影響因子: 3.9

3.Biliary atresia

Tam, Paul K.H., Well More...

Nature Reviews Disease Primers[2056-676X], Published 2024, Volume 10, Issue 1,

收錄情况： WOS SCOPUS

WOS核心合集引用: 2 2023影響因子: 79.0

4.Hirschsprung’s disease

Chung, Patrick, Tam, More...

Essential Paediatric Surgery: A Practical Guide, Published 2024, Pages 57-62

收錄情况： SCOPUS

5.Animal and organoid models to elucidate the anti-fibrotic effect of steroid on biliary atresia

Liu, FR, Lui, VCH, W More...

PEDIATRIC SURGERY INTERNATIONAL[0179-0358], Published 2024, Volume 40, Issue 1,

收錄情况： WOS SCOPUS

WOS核心合集引用: 0 2023影響因子: 1.5

6.Human Liver Organoids to Predict the Outcome of Kasai Portoenterostomy

Wai, Amy Wing Yi, Lu More...

Journal of Pediatric Surgery[0022-3468], Published 2024,

收錄情况： SCOPUS

2023影響因子: 2.4

7.Genetics of Hirschsprung's disease

Tang, CSM, Karim, A, More...

PEDIATRIC SURGERY INTERNATIONAL[0179-0358], Published 2023, Volume 39, Issue 1,

收錄情况： WOS SCOPUS

WOS核心合集引用: 10 2023影響因子: 1.5 发表年影響因子: 1.5

8.Identification of cancer-related genes FGFR2 and CEBPB in choledochal cyst via RNA sequencing of patient-derived liver organoids

Ye, Yongqin, Lui, Vi More...

PLoS ONE[1932-6203], Published 2023, Volume 18, Issue 3 March,

收錄情况： WOS SCOPUS

WOS核心合集引用: 1 2023影響因子: 2.9 发表年影響因子: 2.9

9.Achalasia

Yeung, Fanny, Wong, More...

Pediatric Surgery: Diagnosis and Management, Published 2023, Pages 729-742

收錄情况： SCOPUS

10.Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation

Li, ZX, Lui, KNC, La More...

NATURE COMMUNICATIONS[2041-1723], Published 2023, Volume 14, Issue 1,

收錄情况： WOS SCOPUS

WOS核心合集引用: 3 2023影響因子: 14.7 发表年影響因子: 14.7

More...

成果: 36 匯出

Book Chapter

1.Pediatric Surgery ——Achalasia

Paul Kwong Hang Tam;Patrick Ho Yu Chung

9783642384820 Springer 2020

2.Pediatric Surgery: General Principles and Newborn Surgery ——Clinical Research and Evidence-Based Pediatric Surgery

Dennis K. M. Ip;Kenneth KY Wong;Paul Kwong Hang Tam

9783662435878 Springer 2020

3.Pediatric Surgery ——Achalasia

Paul K. H. Tam;Patrick H. Y. Chung

9783662562802 Springer 2019

4.Hirschsprung's Disease and Allied Disorders ——Genetics of Hirschsprung’s Disease

Paul K. H. Tam;Clara S. M. Tang;Maria-Mercè Garcia-Barceló

9783030156466 Springer Cham 2019

5.Pediatric Surgery ——Omphalomesenteric Duct Remnants

Wong, KKY;Tam, PKH

9783662562802 Springer 2019

6.Newborn Surgery ——Chapter 79, Part 7, Omphalomesenteric duct remnants

Wong KKY; Tam PKH

CRC Press 2018

7.Pediatric Surgery ——Clinical Research and Evidence-Based Pediatric Surgery

Dennis K. M. Ip;Kenneth KY Wong;Paul Kwong Hang Tam

9783642384820 Springer 2017

8.Operative Pediatric Surgery ——Chapter 37, Hernias in children

Jay L Grosfeld;Scott A Engum;Paul KH Tam

9781444117158 Taylor & Francis 2013

9.Stem Cells and Human Diseases ——Chapter 16, Neural crest and Hirschsprung’s disease

Chow KHM; Tam PKH; Ngan ESW

Springer 2012

10.Fundamentals of surgical practice ——Surgical care of the paediatric patient

Tam, PKH

9780521137225 Cambridge University Press 2011

11.Newborn surgery ——Chapter 72, Part VII, Omphalomesenteric duct remnants

Wong, KKY;Tam, PKH

Hodder Arnold 2011

12.Live Cell Imaging: Methods and Protocols ——Chapter 5, Synthetic fluorescent probes for imaging of peroxynitrite and hypochlorous acid in living cells

Yang D; Sun ZN; Peng T; Wang HL; Shen JG; Chen Y; Tam PKH

Humana Press 2010

13.Healing with the scalpel: from the first colonial surgeon to the College of Surgeons of Hong Kong ——Chapter 5, Paediatric Surgery

Liu KKW; Saing H; Tam PKH; Yeung CK

Hong Kong Academy of Medicine Press 2010

14.A History of Surgical Paediatrics ——Hong Kong, Singapore and Vietnam

Tam PKH; Jacobsen AS; Liem NT

World Scientific Publishing Co. Pte. Ltd. 2009

15.Pediatric Surgery: Diagnosis and Management ——Achalasia

Tam PKH; Wong KKY

Springer-Verlag Berlin Heidelberg 2009

16.Fundamentals of Surgical Practice ——Paediatric Surgery

Tam, PKH

9780521677066 Cambridge Unviersity Press 2006

17.Pediatric Surgery ——Achalasia

Paul K. H. Tam

9783642073878 Springer 2006

18.Paediatric Surgery ——Chapter 22, Infantile hypertrophic pyloric stenosis

Tam, PKH;Wong, KKY

Hodder Arnold 2005

19.Operative Endoscopy and Endoscopic Surgery in Infants and Children ——Chapter 5, Instruments used in rigid and flexible endoscopy

Tam, PKH;Wong, KKY

Hodder Arnold 2005

20.Trends in Gene Therapy Research ——Oral viral vector gene delivery

Xu, R;Ma, H;Li, H;Sham, MH;Li, ETS;Tam, PKH;Lam, KSL

1594543062 Nova Sciecen Publishers, Inc. 2005

21.Advanced Surgical Practice ——Chapter 51, Paediatric tumours

Tam, PKH;Lin, CL

Greenwich Medical Media 2003

22.Advanced Surgical Practice ——Chapter 50, Paediatric trauma

Tam, PKH;Lin, CL

Greenwich Medical Media 2002

23.Advanced Surgical Practice ——Chapter 52, Spinal dysraphism

Tam, PKH;Leung, GKK

Greenwich Medical Media 2002

24.Hirschsprung's Disease and Allied Disorders ——Chapter 6, RET protein in human fetal development and in Hirschsprung's disease

Martucciello, G;Tam, PKH

Harwood Academic Publishers 2000

25.Oxford Textbook of Surgery ——Chapter 42.8, The abdominal wall

Tam, PKH

Oxford University Press 2000

26.A Textbook of Paediatric surgery ——Chapter 36, Infantile hypertrophic pyloric stenosis

Tam PKH

Arnold 1998

27.Paediatric Surgery ——Chapter 36, Infantile hypertrophic pyloric stenosis

Tam, PKH

Arnold 1997

28.Fundamentals of Surgical Practice ——Chapter 21, Paediatric surgery

Tam, PKH

Greenwich Medical Media 1997

29.Surgery of the Newborn ——Stomach and gastric outlet

Tam PKH

Churchill Livingstone 1994

30.Oxford Textbook of Surgery ——Paediatric solid tumours

Tam PKH

Oxford University Press 1994

31.Oxford Textbook of Surgery ——The abdominal wall

Gordon AC; Tam PKH

Oxford University Press 1994

32.Neonatal Surgery ——Inguinal hernia

Tam PKH

Butterworths 1990

33.Neonatal Surgery ——Neonatal necrotising enterocolitis

Lister J; Tam PKH

Butterworths 1990

34.Neonatal Surgery ——Meconium and bacterial peritonitis

Lister J; Tam PKH

Butterworths 1990

35.Neonatal Surgery ——Hirschsprung's disease

Lister J; Tam PKH

Butterworths 1990

36.Neonatal Surgery ——Hydrocephalus

Cudmore RE; Tam PKH

Butterworths 1990

More...

成果: 166 匯出

Principal Investigator

2023-2026 [澳門科學技術發展基金項目/ FDCT Projects] UNC5C netrin受體在腸神經系統發育和引致先天性巨結腸的分子機制 = Molecular mechanisms of UNC5C netrin receptor in the development of enteric nervous system and pathogenesis of Hirschsprung disease (Principal Investigator)

2022-2026 [Hong Kong Science and Technology Parks] GLOAS Limited. Incu-Bio Programme (Principal Investigator)

2022-2023 [澳門科技大學研究基金(FRG)項目)/ MUST Faculty Research Grant Projects] ABCA1基因表達改變對小鼠膽道上皮類器官發育及功能的影響 = The study of ABCA1 dysregulation on the developmental and functional effects of biliary organoid in mic (Principal Investigator)

2021-2022 [Research Grant Council Theme-based Research Scheme] Translating Disease-Mechanism Discoveries to Improve Treatment of Biliary Atresia, an Intractable Newborn Liver Disease (Principal Investigator)

2020-2021 [RGC Collaborative Research Fund/CRF] Comparison of paediatric and adult responses to coronavirus infection – a molecular, cellular and tissue study (Principal Investigator)

2020-2021 [RGC General Research Fund] Modelling disease mechanisms and risks of congenital bile-duct dilatation using whole exome sequencing and SNP array data (Principal Investigator)

2019-2021 [Seed Fund for Basic Research] Whole exome sequencing of 8 trios devoid of mutation in the main genes known to underly Hirschsprung disease (Principal Investigator)

2018-2020 [Health and Medical Research Fund/HMRF] Functional genetic study to unravel the genetic background of choledochal cyst (Principal Investigator)

2018-2019 [RGC General Research Fund] The biliary atresia genome: a pilot study to model disease from whole genome sequencing data (Principal Investigator)

2016-2018 [Health and Medical Research Fund/HMRF] Decoding biliary atresia at the transcriptome and tissue architecture level (Principal Investigator)

2016-2018 [Seed Funding Programme for Basic Research] CDD55 and biliary atresia (Principal Investigator)

2015-2017 [RGC General Research Fund] Using genome-editing system to establish human stem cell-based disease model for studying Hirschsprungs (HSCR) associated genetic lesions (Principal Investigator)

2015-2019 [Theme-based Research Scheme] Genetics and functional genomics of neural crest stem cells and associated disease: Hirschsprung disease (Principal Investigator)

2014-2016 [Seed Funding Programme for Basic Research] Generation of isogenic human embryonic stem cells for modeling Hirschsprung's disease (Principal Investigator)

2013-2014 [RGC General Research Fund] Uncovering the genetic lesions underlying persistent cloaca by whole genome sequencing (Principal Investigator)

2012-2013 [RGC General Research Fund] Study on genomic structural variations in Hirschsprung disease (Principal Investigator)

2012-2014 [S.K. Yee Medical Foundation] Advancing laparoscopic skills in China – an extension of the current laparoscopic workshop scheme (Principal Investigator)

2012-2014 [Seed Funding Programme for Basic Research] Study of de novo copy number variations (CNV) in Hirschsprung disease (Principal Investigator)

2011-2012 [The Graduate Research Fund/GRF] Study on genomic structural variations in Hirschsprung's disease GRF Incentive Award (Principal Investigator)

2011-2013 [Seed Funding Programme for Basic Research] Validation of NRG3 copy number variations in the genome of Hirschsprung's patients (Principal Investigator)

2010-2013 [RGC General Research Fund] Deep re-sequencing of Hirschsprung's disease candidate genes (Principal Investigator)

2010-2012 [S.K. Yee Medical Foundation] Establishing S.K. Yee Medical Foundation clinical fellowships (Principal Investigator)

2010-2012 [Seed Funding Programme for Basic Research] NRG1 intron 1 SNPs in Hirschsprung's disease (Principal Investigator)

2009-2011 [S.K. Yee Medical Foundation] Improving the surgical care of sick children in Hong Kong by providing cutting edge minimally invasive and robotic surgery (Principal Investigator)

2008-2009 [France/Hong Kong Joint Research Scheme] Dissecting Hirschsprung's disease: international Hirschsprung's disease consortium (Principal Investigator)

2008-2011 [RGC General Research Fund] Genome-wide association study for the identification of genes underlying anorectal malformation (Principal Investigator)

2008-2010 [S.K. Yee Medical Foundation] Offering surgical care to poor children with major congenital anomalies in rural China (Principal Investigator)

2008-2010 [S.K. Yee Medical Foundation] Establishing a quaternary paediatric gastrointestinal centre for Hong Kong (Principal Investigator)

2008-2010 [URC Seed Funding for Basic Research] Sequencing of the HOXD13 gene in patients with anorectal malformations (Principal Investigator)

2007-2008 [RGC General Research Fund] Study of the genetic basis of biliary atresia (Principal Investigator)

2007-2010 [RGC General Research Fund] Genetic dissection of Hirschsprung's disease (Principal Investigator)

2007-2009 [S.K. Yee Medical Foundation] Offering laparoscopic surgical workshops in China (Principal Investigator)

2007-2009 [URC Seed Funding for Basic Research] Whole genome family based association study to search for RET-dependent modifiers in Hirschsprung's disease (Principal Investigator)

2005-2010 [S.K. Yee Medical Foundation] Further expansion of the “Train-the-Trainers” programme for paediatric surgery in China (Principal Investigator)

2004-2005 [CRCG] Evaluation of HOXB5 as a new Hirschsprung's disease susceptibility locus (Principal Investigator)

2004-2005 [University's Incentive Award] T cell memory and chronic rejection (Principal Investigator)

2003-2004 [CRCG] The study of co-stimulatory function of sonic hedgehog in CD4+ lymphocytes (Principal Investigator)

2003-2007 [S.K. Yee Medical Foundation Grant] Improving the survival and quality of life of children with cancers in China (Principal Investigator)

2003-2004 [University's Incentive Award] The role of T regulatory cell in the long-term survival of orthotropic small bowel allograft (Principal Investigator)

2002-2005 [RGC General Research Fund] Sonic hedgehog signalling in chronic allograft rejection (Principal Investigator)

2002-2003 [URC Seed Funding] The study of T regulatory cell in the indefinite survival of orthotropic small bowel allograft (Principal Investigator)

2001-2004 [RGC General Research Fund] OX40/OX40L-costimulatory pathway in transplantation rejection and tolerance induction (Principal Investigator)

2001-2002 [URC Seed Funding] Investigation of the role of Sox10 gene in enteric nervous system development by explant and organ culture systems (Principal Investigator)

2000-2001 [France/Hong Kong Joint Research Scheme] Analysis of single nucleotide polymorphism (SNPs) of the RET protooncogene in RET associated diseases (Principal Investigator)

2000-2002 [RGC General Research Fund] Multiple molecular approaches for elucidating the multigenic nature of Hirschsprung's disease in Chinese patients (Principal Investigator)

2000-2003 [S.K. Yee Medical Foundation] Expanding the "Train-the-Trainers" programme for paediatric surgery in China (Principal Investigator)

2000-2001 [URC Seed Funding] High throughput analysis of expression profile of genes implicated in enteric neural development and in Hirschsprung's disease in human (Principal Investigator)

1999-2000 [CRCG (seed-funding)] Molecular mechanisms of intestinal ischaemia-reperfusion injury (Principal Investigator)

1999-2001 [Faculty of Medicine(Research Officer appointment in support of Centres of Excellence under the Faculty and Inter-departmental Collaborative Projects)] Molecular mechanisms of intestinal transplant failures: ischaemia-reperfusion injury and immunological rejection (Principal Investigator)

1999-2000 [France/Hong Kong Joint Research Scheme] Analysis of somatic mutations of the ret protooncogene in ret associated diseases (Principal Investigator)

1999- [Fujisawa] New methods of immunosuppression in allogenic small bowel transplantation (Principal Investigator)

1999-2002 [Postdoctoral Fellowship Schemes, University of Hong Kong] Transgenesis animals as bioreactors (Principal Investigator)

1998-1999 [CRCG] Molecular studies of transcription factors implicated in enteric neural development and in Hirschsprung's disease (Principal Investigator)

1998-2000 [Research Associate Professorship Scheme, University of Hong Kong] Molecular study of neural crest disorders (Principal Investigator)

1998-2000 [RGC General Research Fund] Immune mechanisms and new immunosuppressive approaches in small bowel transplantation (Principal Investigator)

1998-2001 [S.K. Yee Medical Foundation] Establishing a “Train-the-Trainers' programme for paediatric surgery in China (Principal Investigator)

1998-2000 [UK/Hong Kong Joint Research Scheme, British Council] The role of neurotrophic factors in Hirschsprung's disease and idiopathic slow transit constipation - a common link? (Principal Investigator)

1997-1998 [Chinese Medicine Research, HKU] Immunosuppressive properties of Tripterygium wolfordii in small bowel transplantation (Principal Investigator)

1997-1998 [Research Student Support Fund] Intestinal failure and experimental small bowel transplantation (Principal Investigator)

1997-1998 [Rotary Club of Kowloon East] Improvement of the care of children with vomiting (Principal Investigator)

1997-1999 [Vice-Chancellor's Development Fund] Transgenesis animals as bioreactors: production of a new immunosuppressive protein CTLA4Ig by transgenesis (Principal Investigator)

1996-1999 [CRCG] Genetic analysis of Hirschsprung's disease (intestinal aganglionosis): clinical pathological-epidemiological correlation (Principal Investigator)

1996- [Fujisawa] New methods of immunosuppression in allogenic small bowel transplantation (Principal Investigator)

1995-1996 [Action Research] Novel immunosuppression in allogenic small bowel transplantation (Principal Investigator)

1995- [Mason Medical Research Foundation] A novel approach to immunosuppression in small bowel transplantation using a HLA class 1 - derived peptide (Principal Investigator)

1995- [Peel Medical Research Trust] Characterisation and identification of genes for Hirschsprung's disease (Principal Investigator)

1995- [Royal College of Surgeons of Edinburgh] The effect of FK506 recipient pretreatment on intragraft cytokine gene expression following small bowel transplantation in rats (Principal Investigator)

1995- [Sir Edward Penley Abraham Research Fund] New approaches of immunosuppression in small bowel transplantation (Principal Investigator)

1994- [Medical Research Fund, University of Oxford] Molecular mechanisms regulating neural crest cell migration in gut during early development (Principal Investigator)

1994- [Royal College of Surgeons of England Research Fellowship] Immune mechanisms of rejection in combined small bowel - liver transplantation (Principal Investigator)

1993-1996 [The Children's Research Fund] Immunological mechanisms of rejection in small bowel transplantation and their modulation with new methods of immunosuppression (Principal Investigator)

1992-1993 [Medical Research Fund, University of Oxford] Immunological mechanisms of rejection of small bowel transplantation (Principal Investigator)

1992- [Peel Medical Trust] Immunological mechanisms of rejection of small bowel transplantation (Principal Investigator)

1991-1996 [John Radcliffe Hospital, Oxford] Immunological mechanisms of rejection of small bowel transplantation (Principal Investigator)

1991- [Medical Insurance Agency Charity] Molecular mechanisms regulating neural crest cell migration in gut during early development (Principal Investigator)

1991-1996 [Oxford Regional Health Authority] Molecular mechanisms regulating neural crest cell migration in gut during early development (Principal Investigator)

1990-1991 [Alder Hey children's Hospital Trust Funds] An immunohistochemical study of Hirschsprung's Disease and related disorders (Principal Investigator)

1990-1991 [The Children's Research Fund] An immunohistochemical study of Hirschsprung's Disease and related disorders (Principal Investigator)

1990- [Wellcome Trust] Molecular biological investigations into the relationship between cytomegalovirus and Hirschsprung's Disease (Principal Investigator)

1989- [Wellcome Trust] Neuron cell adhesion molecules in aganglionic colon in mouse and man (Principal Investigator)

1988- [University of Liverpool Research Grant] Anorectal manometry for bowel motility problems in children (Principal Investigator)

1986-1989 [The Children's Research Fund] Development and abnormalities of enteric nervous system (Principal Investigator)

1986-1987 [Wing Lung Bank Medical Research Fund] Serum gastrin and pepsinogen 1 levels in surgical subjects (Principal Investigator)

1985-1986 [University Research Grant (Hong Kong)] Serum gastrin and pepsinogen 1 levels in surgical subjects (Principal Investigator)

- [Health and Medical Research Fund/HMRF] Whole exome sequencing to uncover genetics variants underlying congenital cystic adenomatoid malformations (Principal Investigator)

- [Health and Medical Research Fund Commissioned PaediatricResearch] Molecular diagnosis of rare genetic diseases: whole genome sequencing and transcriptomics of biliary atresia, Hirschsprung disease and congenital pulmonary airway malformations (Principal Investigator)

- [Health and Medical Research Fund Commissioned PaediatricResearch] To elucidate the role of ‘niche' factors in the pathogenesis of Biliary Atresia using an advanced organoid system (Principal Investigator)

- [Innovation and Technology Fund University-Industry Collaboration Programme] Advancing Diagnosis and Treatment of Two Liver Diseases, Alagille Syndrome and Biliary Atresia, by Organoid and Single Cell Transcriptome Analysis (Principal Investigator)

- [Innovation and Technology Fund University-Industry Collaboration Programme] Establishment of new treatment strategy for neurological diseases using patient specific induced pluripotent stem cells and high-resolution single cell sequencing (Principal Investigator)

Other grants

2003- [The Croucher Foundation] Croucher Advanced Study Institute: Advances and Challenges of Stem Cell Research

2003-2004 [The University of Hong Kong Foundation for Education Development and Research] Biotech Company in the Faculty of Medicine, HKU

2001- [The Croucher Foundation] Croucher Advanced Study Institute: Fundamentals of Human Genetics and Genomic Biology

2000- [Seeding-funding, Faculty of Medicine] Center of Human Development and Birth Defects

2000- [The Croucher Foundation] Croucher Advanced Study Institute: Genetics, Health and Disease in the Post Genome Project Era

Co-Investigator

2020-2021 [RGC General Research Fund] A novel bioinformatics framework for curating and analyzing structural variations from whole genome sequencing data (Co-Investigator)

2019-2021 [Health and Medical Research Fund/HMRF] A sensitized genetic screen to identify and functionally characterize genetic modifiers for Hirschsprung disease (Co-Investigator)

2019-2021 [RGC General Research Fund] Functional genomics to investigate cholangiocyte cilia dysfunctions in biliary atresia (Co-Investigator)

2017-2019 [Health and Medical Research Fund/HMRF] Identification and functional characterization of Hirshsprung disease susceptibility genes on chromosome 21 (Co-Investigator)

2016-2018 [Innovation and Technology Support Programme (Tier 2)] Establishing a molecular encyclopedia for stem cell and regenerative medicine: Heart (Co-Investigator)

2015-2017 [Health and Medical Research Fund/HMRF] The International Hirschsprung Disease Consortium: follow-up on whole-exome sequencing data (Co-Investigator)

2015-2017 [Seed Funding Programme for Basic Research] Anorectal malformations: transethnic follow-up on DDK4 (Co-Investigator)

2014-2017 [RGC General Research Fund] Causative genes for perinatal biliary atresia: a follow-up of whole-exome sequencing (Co-Investigator)

2014-2016 [Seed Funding Programme for Basic Research] Villin 1 (VIL1) mutations in biliary atresia patients: a coincidence? (Co-Investigator)

2014-2016 [Seed Funding Programme for Basic Research] Do de novo chromosomal abnormalities lead to sporadic biliary atresia? (Co-Investigator)

2014-2015 [Small Project Funding] Copy number variation in syndromic Hirschsprung disease patients (Co-Investigator)

2013-2014 [Health and Medical Research Fund/HMRF] Uncovering the genetic lesions underlying the most severe form of Hirschsprung (HSCR) disease by whole genome sequencing (WGS): a pilot study in 8 family trios (Co-Investigator)

2013-2014 [Health and Medical Research Fund/HMRF] Potential use of patient specific induced-pluriopotent stem cell (iPSC) to define genetic lesions contributing to the disease phenotypes of syndromic Hirschsprung (HSCR) (Co-Investigator)

2013-2014 [Health and Medical Research Fund/HMRF] Functional genetics study to unravel the genetic background of a complex neurodevelopmental disorder namely Hirschsprung disease (Co-Investigator)

2013-2014 [RGC General Research Fund] Congenital dilatation of the bile ducts (CCD): a genetic study (Co-Investigator)

2012-2013 [RGC General Research Fund] Whole-exome sequencing to uncover causative genes for perinatal biliary atresia (Co-Investigator)

2011-2012 [RGC General Research Fund] Whole-exome sequencing to identify genes underlying Caudal Regression Syndrome (Co-Investigator)

2011-2012 [RGC General Research Fund] Transcriptional regulation of RET in Hirschsprung's disease (Co-Investigator)

2011-2013 [Seed Funding Programme for Basic Research] Investigation of structural variations in Caudal Regression Syndrome Patients (Co-Investigator)

2011-2013 [Seed Funding Programme for Basic Research] Meta-analysis of Chinese and European genome-wide association studies of Hirschsprung's disease and confirmation of novel loci (Co-Investigator)

2010-2012 [Innovation and Technology Support Programme] Next generation high-throughput and targeted DNA sequencing platforms for systematic discovery of novel diagnostic markers of common disease (Co-Investigator)

2010-2011 [RGC General Research Fund] Prokineticin signalling in neuroblastoma (Co-Investigator)

2010-2011 [RGC General Research Fund] Premature gliogenesis of enteric neural crest cells induced by aberrant Sonic hedgehog-Notch signalling: a cause of Hirschsprung diseases? (Co-Investigator)

2010-2012 [S.K. Yee Medical Foundation] Development of minimally invasive surgery service for children in centres in rural China (Co-Investigator)

2010-2012 [Seed Funding Programme for Basic Research] Exon sequencing of Semaphorin, a novel Hirschsprung's disease susceptibility locus (Co-Investigator)

2009-2010 [RGC General Research Fund] Fine mapping of Hirschsprung's disease loci on the 3p21 and 9q31 candidate regions (Co-Investigator)

2009-2011 [RGC General Research Fund] Thyroid transcription factor-1 (TTF-1), a potential susceptibility gene for familial papillary thyroid carcinoma (Co-Investigator)

2009-2011 [RGC General Research Fund] Identification of functional variants in Neuregulin-1 (NRG1), a newly discovered Hirschsprung disease gene (Co-Investigator)

2009-2011 [Seed Project Funding] Inkjet printing of tissue-engineered skin construct for vascular regeneration in wound healing (Co-Investigator)

2008-2011 [RGC General Research Fund] Genome-wide association study of schizophrenia (Co-Investigator)

2008-2010 [RGC General Research Fund] Functional evaluation of RET coding and non-coding sequence mutations in Hirschsprung's disease (Co-Investigator)

2008-2011 [RGC General Research Fund] HOXB5 and RET promoter: regulation of RET transcription in Hirschsprung's disease (Co-Investigator)

2008-2010 [RGC General Research Fund] The role of adiponectin in cardiac allograft survival and immune regulation (Co-Investigator)

2007-2009 [RGC General Research Fund] Investigation of cell autonomous function of Hedgehog signaling on vagal neural crest cells by conditional knockout of Smoothened in mice (Co-Investigator)

2007-2010 [RGC General Research Fund] Molecular characterization of the transcriptional regulatory elements involved in the synergistic induction of heme oxygenase-1 expression by traditional Chinese medicines (Co-Investigator)

2007-2008 [URC Seed Funding] Functional analysis of RET coding region mutations (Co-Investigator)

2006-2008 [RGC General Research Fund] Study of the molecular basis of anorectal malformations (Co-Investigator)

2005-2008 [RGC General Research Fund] Functional analysis of Hoxb5 in enteric neurons in mice (Co-Investigator)

2005-2008 [RGC General Research Fund] Investigating the moleculars basis of Sox10 functions in enteric nervous system development using a series of mutant mouse models (Co-Investigator)

2005-2006 [URC Seed Funding] Study of the molecular basis of anorectal malformations (Co-Investigator)

2004-2006 [RGC General Research Fund] Conditional knockout of Patched gene in enteric neural crest cells: functional study of the role of Hedgehog signaling in enteric nervous system development (Co-Investigator)

2004-2007 [RGC General Research Fund] RET regulatory polymorphisms and susceptibility to Hirschsprung's disease (Co-Investigator)

2003- [Innovation and Technology Fund] A haplotype map (HapMap) of the human genome – Hong Kong contribution (Co-Investigator)

2003-2005 [RGC General Research Fund] Regulation of gene transcription by NF-kB and stats downstream of the ret receptor tyrosine kinase in Hirschsprung disease and thyroid cancer (Co-Investigator)

2003-2005 [RGC General Research Fund] Epigenetic and genetic deregulation in pediatric solid tumors (Co-Investigator)

2003- [University Grant Committee] A haplotype map (HapMap) of the human genome – Hong Kong contribution (Co-Investigator)

2002-2004 [RGC General Research Fund] Engrailed-Hoxb5 chimaeric transcription repressor: a novel approach to investigate Hoxb5 function in enteric neurons and gut development in transgenic mice (Co-Investigator)

2001- [URC Seed Funding] The effect of tryptophan metabolism on the regulation of function and migration of dendritic cells (Co-Investigator)

2000- [Queen Mary Hospital Charity Ltd - Training and Research Assistant Scheme] Can nitric oxide donors protect premature babies from necrotising enterocolitis (Co-Investigator)

2000-2001 [RGC Earmarked Grants] Defining the role of RET receptor tyrosine kinase in enteric neurogenesis (Co-Investigator)

2000- [URC Seed Funding] Role of GFRs in the development of enteric nervous system and in the aetiology of Hirschsprung's disease (Co-Investigator)

2000- [URC Seed Funding] Novel approach in induction of donor specific tolerance in small bowel transplantation model in rat: a pre-clinical study (Co-Investigator)

2000- [URC Seed Funding] Study the expression of 3' splicing veriants of RET protooncogene in mouse embryogenesis (Co-Investigator)

2000- [URC Seed Funding] Pathogenetic role of macrophage migration inhibitory factor in necrotizing enterocolitis (Co-Investigator)

1999-2000 [CRCG] Inner ear abnormalities in children with Hirschsprung's disease (Co-Investigator)

1999- [France/Hong Kong Joint Research Scheme] Studying the role of Sox 10 and Krox-20 genes in the migration and differentiation of vagel neural crest cells using the Dominant megacolon mutant mice (Co-Investigator)

1999- [RGC Earmarked Grants] Transgenic mouse models for studying the role of mouse SOX10 gene in enteric nervous system development (Co-Investigator)

1998-1999 [CRCG] Hirschsprung's disease may not be a localised neuropathy: an intestinal transit and autonomic and sensory nerve function study (Co-Investigator)

1997-1998 [Chinese Medicine Research, HKU] Acupressure for the prevention of nausea and vomiting complicating chemotherapy in children: an electrogastrographic study (Co-Investigator)

1997-1998 [CRCG] The effect of adriamycin on apoptosis in recanalization of duodenum in fetal rats (Co-Investigator)

1997-1998 [CRCG] Ileocolic intussusception and its variants: a sonographic-pathological correlative study (Co-Investigator)

1987-1989 [Pharmax Ltd and Roussel Laboratories Ltd] Selective decontamination on colonisation and infection rates in a neonatal surgical unit (Co-Investigator)

1985-1986 [University Research Grant (Hong Kong)] Evaluation of diagnostic techniques and early and late results of the treatment of biliary atresia to hepaticoportoenterostomy (Co-Investigator)

1985-1987 [University Research Grant (Hong Kong)] Gastric emptying after posterior trunkal vagotomy with seromyotomy of the anterior lesser curve assessed by epigastric impedance (Co-Investigator)

- [Health and Medical Research Fund/HMRF] Towards establishing a genetic risk profile for Hirschsprung disease: pathway-centric approach to model polygenic risk (Co-Investigator)

- [Health and Medical Research Fund/HMRF] Functional interrogation of non-coding regulatory regions identified from Hirschsprung disease patients (Co-Investigator)

- [Health and Medical Research Fund/HMRF] Organoid systems to study the effect of steroid in modulating immune-mediated inflammation in biliary atresia: a bridge to therapeutic application (Co-Investigator)

- [RGC Central Allocation for fundable not funded project] A clinico-radiologico-pathological study of the development, progression and treatment of intussusception using an animal model (Co-Investigator)

- [S.K. Yee Medical Research Fund] Neural crest-derived cells: role in functional repair of the nervous system (Co-Investigator)

- [S.K. Yee Medical Research Fund] Provision of modern surgical care to poor children with congenital anomalies in southern China (Co-Investigator)

Shortlisted Research Grant Proposal

2021-2022 [RGC Collaborative Research Fund/CRF] Integrative multi-omics and niche biology approach for precision medicine of Hirschsprung disease (Co-Principal Investigator)

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成果: 11 匯出

1.AMYLOID PRECURSOR PROTEIN AS A DIAGNOSTIC MARKER FOR BILIARY ATRESIA

Chi Hang LUI,Paul Kw More...

專利權人: Versitech Limited More...

申請號: US17418732 申請日: 2020/1/13

公開（公告）號: US20220065871A1 公開（公告）日期: 2022/3/3

IPC分類號: G01N33/68; C12Q1/6883

法律狀態: 实质审查

同族信息: WO2020156128A1; US20220065871A1; CN113474468A

2.AMYLOID PRECURSOR PROTEIN AS A DIAGNOSTIC MARKER FOR BILIARY ATRESIA

LUI Chi Hang,OTTAKAN More...

專利權人: Versitech Limited More...

申請號: WOCN20071742 申請日: 2020/1/13

公開（公告）號: WO2020156128A1 公開（公告）日期: 2020/8/6

IPC分類號: C12Q1/68; C12Q1/6883; G01N33/573

法律狀態: 未进入国家阶段-PCT有效期满

同族信息: WO2020156128A1; US20220065871A1; CN113474468A

3.COMBINATION OF AN IMMUNOSUPPRESSANT AND A PPAR GAMMA AGONIST FOR THE TREATMENT OF AN UNDESIRABLE IMMUNE RESPONSE

LAMB Jonathan Robert More...

專利權人: SmithKline Beecham ( More...

申請號: HK09100799.4 申請日: 2009/1/23

公開（公告）號: HK1122740A 公開（公告）日期: 2009/5/29

IPC分類號: A61K31/365; A61K31/426; A61K38/13; A61P17/06; A61P19/02; A61P37/00; A61P37/06

法律狀態: Withdrawn

同族信息: HK1122740A

4.COMBINATION OF AN IMMUNOSUPPRESSANT AND A PPAR GAMMA AGONIST FOR THE TREATMENT OF AN UNDESIRABLE IMMUNE RESPONSE

LAMB Jonathan Robert More...

專利權人: SB Pharmco Puerto Ri More...

申請號: EP06709929 申請日: 2006/2/28

公開（公告）號: EP1959950A1 公開（公告）日期: 2008/8/27

IPC分類號: A61K31/365; A61K31/426; A61K38/13; A61P17/06; A61P19/02; A61P37/00; A61P37/06

法律狀態: 撤回

同族信息: WO2006092580A1; GB0504206D0; JP2008531669A; EP1959950A1; US20090082260A1

5.COMBINATION OF AN IMMUNOSUPPRESSANT AND A PPAR GAMMA AGONIST FOR THE TREATMENT OF AN UNDESIRABLE IMMUNE RESPONSE

Jonathan Robert Lamb More...

專利權人: LAMB JONATHAN ROBERT More...

申請號: US11816933 申請日: 2006/2/28

公開（公告）號: US20090082260A1 公開（公告）日期: 2009/3/26

IPC分類號: A61K38/13; A61K31/421; A61K31/426; A61K31/436; A61K31/4439; A61P1/00; A61P37/00; A61P37/06

法律狀態: 放弃

同族信息: WO2006092580A1; GB0504206D0; JP2008531669A; EP1959950A1; US20090082260A1

6.COMBINATION THERAPY

LAMB Jonathan Robert More...

專利權人: SB PHARMCO PUERTO RI More...

申請號: WOGB06000705 申請日: 2006/2/28

公開（公告）號: WO2006092580A1 公開（公告）日期: 2006/9/8

IPC分類號: A61K31/365; A61K31/426; A61K38/13; A61P17/06; A61P19/02; A61P37/00; A61P37/06

法律狀態: 进入国家阶段-PCT有效期满

同族信息: WO2006092580A1; GB0504206D0; JP2008531669A; EP1959950A1; US20090082260A1

7.PHOX2B polymorphisms as Hirschsprung's disease diagnostic markers and methods based thereon

Benedict Ling Sze Ch More...

專利權人: Maria Mercedes Garci More...

申請號: US10408501 申請日: 2003/4/7

公開（公告）號: US7198898B2 公開（公告）日期: 2007/4/3

IPC分類號: C12Q1/68; C07K14/72; C12P19/34

法律狀態: 授权

同族信息: WO03087359A1; US7198898B2; AU2003218601A1; US20030224424A1

8.PHOX2B polymorphisms as Hirschsprung's disease diagnostic markers and methods based thereon

Benedict Ling Sze Ch More...

專利權人: GARCIA BARCELO MARIA More...

申請號: US10408501 申請日: 2003/4/7

公開（公告）號: US20030224424A1 公開（公告）日期: 2003/12/4

IPC分類號: C12Q1/68; C07H21/04; C12N9/02; C12P21/02; C12N5/06; C07K14/72

法律狀態: 授权

同族信息: WO03087359A1; US7198898B2; AU2003218601A1; US20030224424A1

9.PHOX2B polymorphisms as Hirschsprung's disease diagnostic markers and methods based thereon

BARCELO Maria Merced More...

專利權人: THE UNIVERSITY OF HO More...

申請號: AU2003218601 申請日: 2003/3/31

公開（公告）號: AU2003218601A1 公開（公告）日期: 2003/10/27

IPC分類號: C12N15/09; C12N15/10; C12N15/11; C07K14/00; C07K14/72

法律狀態: 撤回

同族信息: WO03087359A1; US7198898B2; AU2003218601A1; US20030224424A1

10.PHOX2B polymorphisms as Hirschsprung's disease diagnostic markers and methods based thereon

BARCELO Maria Merced More...

專利權人: THE UNIVERSITY OF HO More...

申請號: WOCN03000231 申請日: 2003/3/31

公開（公告）號: WO03087359A1 公開（公告）日期: 2003/10/23

IPC分類號: C12N15/09; C12N15/10; C12N15/11; C07K14/00; C07K14/72

法律狀態: 进入国家阶段-PCT有效期满

同族信息: WO03087359A1; US7198898B2; AU2003218601A1; US20030224424A1

More...